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Casting

E. G. Daily
E. G. DailyTommy Pickles (voice)
Nancy Cartwright
Nancy CartwrightChuckie Finster (voice)
Cheryl Chase
Cheryl ChaseAngelica Pickles (voice)
Cree Summer
Cree SummerSusie Carmichael (voice)
Kath Soucie
Kath SouciePhil DeVille / Lil DeVille (voice)
Ashley Rae Spillers
Ashley Rae SpillersDidi Pickles (voice)
Tommy Dewey
Tommy DeweyStu Pickles (voice)
Tony Hale
Tony HaleChas Finster (voice)
Natalie Morales
Natalie MoralesBetty DeVille (voice)
Anna Chlumsky
Anna ChlumskyCharlotte Pickles (voice)
Timothy Simons
Timothy SimonsDrew Pickles (voice)
Nicole Byer
Nicole ByerLucy Carmichael (voice)
Omar Benson Miller
Omar Benson MillerRandy Carmichael (voice)
Michael McKean
Michael McKeanGrandpa Lou Pickles (voice)